Based on the history that you narrated, you were initially treated for vivax malaria with chloroquine and primaquine. Afterwards , you were treated for falciparum malaria with artemether and lumefentarine (80/480). Investigations alone are not the criteria for suspecting malaria in a patient. Contributing evidence such as prevalent specie in the area, presence of thrombocytopenia (low platelets on blood counts) with splenomegaly (enlarged spleen on ultrasound ) and classical high grade fever should be taken into consideration when deciding on the treatment. 

Empiric treatment with antibiotics is also now considered in addition to the antimalarial therapy as it can reduce the burden of possible sepsis as a complication. The fever now is low grade and you have been treated twice for malaria. Most likely the malaria is cured. 

Blood culture will not give any info with respect to malaria. If there is bacterial involvement then blood cultures can be of use in this situation especially if the fever is not subsiding. Document the temperature for 24 to 48 hours. If there is a spike despite taking the above treatment then IV artesunate for malaria if suspected , blood cultures and further workup can be planned. If you remain afebrile then there is no need for extensive workup.

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AskMDx Team.